Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634529 | 0.90 | PDE3B (0.43) | ADORA2AADORA2BPDE2APDE3BPDE3A | |
| SCHEMBL9635749 | 0.88 | LPAR2 (0.43) | ADORA2AADORA2BPDE3BPDE3AP2RY12 | |
| SCHEMBL9634292 | 0.87 | PDE5A (0.49) | ADORA2AADORA2BPDE2APDE3BPDE3A | |
| SCHEMBL9634389 | 0.86 | MAPT (0.45) | ADORA2AADORA2BPDE2APDE3BPDE3A | |
| SCHEMBL9634800 | 0.86 | ADORA2A (0.54) | ADORA2AADORA2BPDE3BPDE3AP2RY12 | |
| SCHEMBL9634973 | 0.85 | CBFB (0.46) | MAPTLMNAGAAMEN1KMT2A | |
| SCHEMBL9635832 | 0.84 | CHEK2 (0.42) | PDE2APDE3BPDE3AP2RY12MAPT | |
| SCHEMBL9635773 | 0.84 | PDE3B (0.39) | ADORA2AADORA2BPDE2APDE3BPDE3A | |
| SCHEMBL9636296 | 0.84 | PDE3B (0.39) | ADORA2AADORA2BPDE2APDE3BPDE3A | |
| SCHEMBL9636119 | 0.83 | MEN1 (0.56) | ADORA2AADORA2BPDE2APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |