Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.42 |
| ▸ | PDE5A | O76074 | 5/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636138 | 0.89 | PDE5A (0.46) | CHEK2PDE3BPDE3AP2RY12PDE5A | |
| SCHEMBL9634973 | 0.87 | CBFB (0.46) | CHEK2PDE5AMGAMGAASI | |
| SCHEMBL14601539 | 0.86 | CHEK2 (0.46) | CHEK2PDE3BPDE3AP2RY12PDE5A | |
| SCHEMBL9634828 | 0.85 | PDE5A (0.45) | CHEK2PDE3BPDE3AP2RY12PDE5A | |
| SCHEMBL9634947 | 0.85 | PDE5A (0.46) | CHEK2PDE3BPDE3APDE5AAMY1A | |
| SCHEMBL9635668 | 0.84 | LMNA (0.40) | PDE3BPDE3APDE5AAMY1AMAOA | |
| SCHEMBL9634572 | 0.84 | ADORA2A (0.48) | PDE3BPDE3AP2RY12AMY1APDE2A | |
| SCHEMBL9635887 | 0.84 | AMY1A (0.38) | PDE3BPDE3APDE5AAMY1AMGAM | |
| SCHEMBL9635821 | 0.84 | CYP1A1 (0.38) | PDE3BPDE3APDE5AAMY1AMAOA | |
| SCHEMBL9635766 | 0.84 | CHEK2 (0.55) | CHEK2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |