Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.67 |
| ▸ | FAAH | O00519 | 1/20 | 0.60 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.60 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634921 | 0.88 | AURKA (0.60) | AURKAFAAHPRMT5HPSE | |
| SCHEMBL9635808 | 0.87 | AURKA (0.69) | AURKAFAAHPRMT5HPSEKMT2A | |
| SCHEMBL9635691 | 0.86 | PRMT5 (0.67) | AURKAFAAHPRMT5HPSEKMT2A | |
| SCHEMBL9635045 | 0.86 | AURKA (0.58) | AURKAFAAHPRMT5HPSE | |
| SCHEMBL9634326 | 0.85 | AURKA (0.57) | AURKAFAAHPRMT5HPSE | |
| SCHEMBL9634845 | 0.84 | PDE2A (0.56) | AURKAFAAHHPSEKMT2A | |
| SCHEMBL9635762 | 0.84 | AURKA (0.55) | AURKAFAAHPRMT5HPSE | |
| SCHEMBL9634958 | 0.83 | PDE2A (0.64) | AURKAFAAHKMT2A | |
| SCHEMBL9636415 | 0.82 | PDE2A (0.72) | AURKAFAAHKMT2A | |
| SCHEMBL9634583 | 0.81 | PDE2A (0.60) | AURKAFAAHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |