Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.69 |
| ▸ | FAAH | O00519 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634633 | 0.89 | AURKA (0.63) | AURKAFAAHHPSEPRMT5DYRK3 | |
| SCHEMBL9635708 | 0.87 | AURKA (0.66) | AURKAFAAHKMT2AHPSEPRMT5 | |
| SCHEMBL9634574 | 0.87 | AURKA (0.67) | AURKAFAAHKMT2AHPSEPRMT5 | |
| SCHEMBL9634845 | 0.83 | PDE2A (0.56) | AURKAFAAHKMT2AHPSEKDM4E | |
| SCHEMBL9634958 | 0.83 | PDE2A (0.64) | AURKAFAAHKMT2AKDM4EMEN1 | |
| SCHEMBL9636415 | 0.82 | PDE2A (0.72) | AURKAFAAHKMT2AKDM4EMEN1 | |
| SCHEMBL9635829 | 0.81 | HDAC6 (0.50) | AURKAKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL9634583 | 0.80 | PDE2A (0.60) | AURKAFAAHKMT2AKDM4EMEN1 | |
| SCHEMBL9636127 | 0.77 | PDE5A (0.68) | AURKAKMT2AKDM4EALDH1A1 | |
| SCHEMBL14091548 | 0.77 | AURKA (0.68) | AURKAFAAHPRMT5DYRK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |