Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | PDE5A | O76074 | 3/20 | 0.53 |
| ▸ | PDE4A | P27815 | 3/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634326 | 0.98 | AURKA (0.57) | AURKAPDE5APDE4APDE4BPDE4C | |
| SCHEMBL9635045 | 0.93 | AURKA (0.58) | AURKAPDE5APDE4APDE4BPDE4C | |
| SCHEMBL9634921 | 0.88 | AURKA (0.60) | AURKAPRMT5FAAHHPSE | |
| SCHEMBL9634574 | 0.84 | AURKA (0.67) | AURKAPRMT5FAAHHPSE | |
| SCHEMBL9634818 | 0.81 | HDAC3 (0.47) | PDE5A | |
| SCHEMBL9635691 | 0.80 | PRMT5 (0.67) | AURKAPRMT5FAAHHPSE | |
| SCHEMBL9635755 | 0.78 | ATP4A (0.48) | — | |
| SCHEMBL9634633 | 0.77 | AURKA (0.63) | AURKAPDE5APRMT5FAAHHPSE | |
| SCHEMBL14091556 | 0.74 | ACHE (0.70) | AURKAPDE5APDE4APDE4BPDE4C | |
| SCHEMBL9635647 | 0.74 | ADORA2A (0.55) | AURKAPDE5APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |