Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.63 |
| ▸ | FAAH | O00519 | 2/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635808 | 0.89 | AURKA (0.69) | AURKAFAAHPRMT5HPSEDYRK3 | |
| SCHEMBL9634921 | 0.88 | AURKA (0.60) | AURKAFAAHPRMT5HPSE | |
| SCHEMBL9635708 | 0.85 | AURKA (0.66) | AURKAFAAHPRMT5HPSE | |
| SCHEMBL9635647 | 0.84 | ADORA2A (0.55) | AURKAFAAHPDE3BPDE3AP2RY12 | |
| SCHEMBL9635727 | 0.83 | PDE2A (0.58) | AURKAFAAHPDE3BPDE3AP2RY12 | |
| SCHEMBL9636183 | 0.82 | PDE5A (0.59) | AURKAFAAHPDE3BPDE3AP2RY12 | |
| SCHEMBL9635684 | 0.82 | PDE2A (0.68) | AURKAPDE3BPDE3AP2RY12PDE5A | |
| SCHEMBL9634891 | 0.81 | PDE3B (0.48) | PDE3BPDE3AP2RY12PKN2F9 | |
| SCHEMBL9635045 | 0.80 | AURKA (0.58) | AURKAFAAHPRMT5HPSEPDE5A | |
| SCHEMBL9634326 | 0.79 | AURKA (0.57) | AURKAFAAHPRMT5HPSEPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |