Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.32 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634788 | 0.88 | AMY1A (0.38) | PDE5APDE3BPDE3AJMJD6PDE4A | |
| Isomazole SCHEMBL145963 | 0.87 | PDE5A (0.51) | PDE5APDE3BPDE3AALDH1A1KDM4E | |
| Isomazole SCHEMBL30578156 | 0.87 | PDE5A (0.51) | PDE5APDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL7279662 | 0.86 | AMY1A (0.39) | PDE5APDE3BPDE3AJMJD6ALDH1A1 | |
| SCHEMBL9635868 | 0.86 | AMY1A (0.40) | PDE5APDE3BPDE3AJMJD6ALDH1A1 | |
| Isomazole SCHEMBL121627 | 0.86 | PDE5A (0.51) | PDE5APDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL10737627 | 0.85 | PDE5A (0.35) | PDE5APDE3BPDE3AALDH1A1HPGD | |
| SCHEMBL9635768 | 0.84 | PDE5A (0.44) | PDE5APDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL7278405 | 0.84 | ALDH1A1 (0.39) | PDE5APDE3BPDE3AJMJD6ALDH1A1 | |
| SCHEMBL9636112 | 0.84 | PDE5A (0.41) | PDE5APDE3BPDE3AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |