Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635456 | 0.91 | GLO1 (0.62) | CYSLTR1GLO1PDE10AALOX5ALOX5AP | |
| SCHEMBL10718365 | 0.75 | GLO1 (0.74) | GLO1AKR1B1 | |
| SCHEMBL26771348 | 0.73 | GPBAR1 (0.81) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL26771305 | 0.71 | GPBAR1 (0.83) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL13772898 | 0.71 | CYSLTR1 (0.69) | CYSLTR1PDE10AGPBAR1ALOX5 | |
| SCHEMBL26771346 | 0.71 | CYSLTR1 (0.66) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 | |
| SCHEMBL7718896 | 0.70 | GPBAR1 (0.90) | CYSLTR1PDE10AGPBAR1ALOX5FFAR1 | |
| SCHEMBL7457682 | 0.70 | GPBAR1 (0.90) | CYSLTR1PDE10AGPBAR1ALOX5FFAR1 | |
| SCHEMBL26771313 | 0.70 | CYSLTR1 (0.80) | CYSLTR1GPBAR1FFAR1AKR1B1 | |
| SCHEMBL9757229 | 0.70 | ALOX5 (0.47) | CYSLTR1GPBAR1ALOX5FFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082849-A | Antiinflammatory agents or antiallergens | AVENTIS PHARMACEUTICALS INC. | 1992-01-21 | — | — | US | disclosed |
| EP-0434827-A4 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1992-01-08 | — | — | EP | disclosed |
| EP-0434827-A1 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| WO-1991001123-A2 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-02-07 | — | — | WO | disclosed |
| US-4977162-A | Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments | RORER PHARMACEUTICAL CORPORATION (US) | 1990-12-11 | — | — | US | disclosed |