Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11369382 | 0.82 | KDM4E (0.68) | KDM4EALDH1A1AKT1MAPTHTR2C | |
| SCHEMBL11105407 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1AKT1MAPTHTR2C | |
| SCHEMBL9635634 | 0.76 | KDM4E (0.56) | KDM4EALDH1A1AKT1MAPTHTR2C | |
| SCHEMBL11112069 | 0.76 | KDM4E (0.59) | KDM4EALDH1A1AKT1MAPTHTR2C | |
| SCHEMBL9635631 | 0.74 | KDM4E (0.54) | KDM4EALDH1A1AKT1MAPTHTR2C | |
| SCHEMBL1983108 | 0.73 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTHTR2CMAOB | |
| SCHEMBL30132496 | 0.73 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTHTR2CMAOB | |
| SCHEMBL3029269 | 0.72 | ALDH1A1 (0.66) | KDM4EALDH1A1AKT1MAPTHTR2C | |
| SCHEMBL11105391 | 0.71 | KDM4E (0.56) | KDM4EALDH1A1AKT1MAPTHTR2C | |
| SCHEMBL9757008 | 0.71 | BRD4 (0.33) | KDM4EALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082849-A | Antiinflammatory agents or antiallergens | AVENTIS PHARMACEUTICALS INC. | 1992-01-21 | — | — | US | disclosed |
| EP-0434827-A1 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| WO-1991001123-A2 | QUINOLINYL-BENZOPYRAN DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-02-07 | — | — | WO | disclosed |
| US-4977162-A | Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments | RORER PHARMACEUTICAL CORPORATION (US) | 1990-12-11 | — | — | US | disclosed |