Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634585 | 0.88 | PDE5A (0.61) | PDE5AEPHX2ADORA3KDM4EALDH1A1 | |
| SCHEMBL9635775 | 0.85 | KDM4E (0.53) | PDE5AEPHX2ADORA3KDM4EALDH1A1 | |
| SCHEMBL9636041 | 0.84 | MEN1 (0.45) | PDE5AEPHX2ADORA3KDM4EALDH1A1 | |
| SCHEMBL9634681 | 0.83 | KMT2A (0.46) | PDE5AKDM4EALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL9635919 | 0.81 | KDM4E (0.42) | PDE5AEPHX2ADORA3KDM4EALDH1A1 | |
| SCHEMBL9635740 | 0.81 | KDM4E (0.56) | PDE5AEPHX2ADORA3KDM4EALDH1A1 | |
| SCHEMBL7270979 | 0.80 | ALOX5 (0.51) | PDE5AEPHX2ADORA3KDM4EALDH1A1 | |
| SCHEMBL9636078 | 0.79 | ALDH1A1 (0.61) | PDE5AKDM4EALDH1A1NPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10845977 | 0.79 | PDE5A (0.50) | PDE5AEPHX2ADORA3KDM4EALDH1A1 | |
| SCHEMBL9635651 | 0.78 | ALDH1A1 (0.53) | PDE5AKDM4EALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |