Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.65 |
| ▸ | AURKA | O14965 | 6/20 | 0.65 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634908 | 0.87 | PRMT5 (0.65) | PRMT5AURKAHPSEFAAHMETAP2 | |
| SCHEMBL9634626 | 0.86 | AURKA (0.67) | PRMT5AURKAHPSEFAAHMETAP2 | |
| SCHEMBL9636535 | 0.82 | PDE2A (0.62) | PRMT5AURKAPDE2A | |
| SCHEMBL9634777 | 0.82 | PDE5A (0.57) | PRMT5AURKAPDE2A | |
| SCHEMBL23743183 | 0.81 | NPC1 (0.61) | — | |
| SCHEMBL10741124 | 0.81 | PRMT5 (0.42) | PRMT5AURKAMETAP2METAP1 | |
| SCHEMBL11772846 | 0.79 | AURKA (1.00) | PRMT5AURKAHPSEMETAP2METAP1 | |
| SCHEMBL15972282 | 0.79 | PRMT5 (1.00) | PRMT5AURKA | |
| SCHEMBL9634375 | 0.79 | PDE2A (0.75) | AURKAPDE2A | |
| SCHEMBL9635006 | 0.78 | AURKA (0.68) | PRMT5AURKAHPSEMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |