Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 11/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10739608 | 0.86 | CYP1A1 (0.52) | PRMT5METAP2METAP1AURKACYP1A1 | |
| SCHEMBL10736622 | 0.84 | AURKA (0.46) | METAP2METAP1AURKA | |
| SCHEMBL10737285 | 0.81 | TBK1 (0.53) | PRMT5METAP2METAP1AURKASYK | |
| SCHEMBL9635700 | 0.81 | PRMT5 (0.65) | PRMT5METAP2METAP1AURKA | |
| SCHEMBL10734507 | 0.81 | PDE2A (0.41) | METAP2METAP1AURKASYKCYP1A2 | |
| SCHEMBL10735463 | 0.81 | SYK (0.39) | METAP2METAP1AURKASYK | |
| SCHEMBL10737690 | 0.79 | CYP2D6 (0.55) | AURKACYP1A2 | |
| SCHEMBL10734763 | 0.79 | RAB9A (0.52) | PRMT5METAP2METAP1AURKACYP1A2 | |
| SCHEMBL10736467 | 0.78 | PDE2A (0.52) | PRMT5METAP2METAP1AURKACYP1A2 | |
| SCHEMBL10738052 | 0.78 | AURKA (0.64) | PRMT5METAP2METAP1AURKATBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4654344-A | ALSO AFFECT BLOOD PRESSURE AND MYOCARDIAL CONTRACTIONS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-03-31 | — | — | US | disclosed |
| EP-0093951-B1 | 2-ARYL-TETRAAZAINDENES | MERCK PATENT GmbH (DE) | 1986-10-29 | — | — | EP | disclosed |
| US-4575505-A | Pharmaceutical compositions containing 2-aryltetraazaindenes for treating ulcers or cardiac insufficiency or blood pressure abnormalities | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-03-11 | — | — | US | disclosed |
| US-4477454-A | INDOTROPIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-16 | — | — | US | disclosed |
| EP-0093951-A2 | 2-Aryl-tetraazaindenes | MERCK PATENT GmbH (DE) | 1983-11-16 | — | — | EP | disclosed |