Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.68 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.61 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.53 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634908 | 0.84 | PRMT5 (0.65) | AURKAPRMT5HPSEMETAP1METAP2 | |
| SCHEMBL11772846 | 0.81 | AURKA (1.00) | AURKAPRMT5HPSEMETAP1METAP2 | |
| SCHEMBL10737096 | 0.80 | METAP2 (0.44) | AURKAPRMT5HPSEMETAP1METAP2 | |
| SCHEMBL9635700 | 0.78 | PRMT5 (0.65) | AURKAPRMT5HPSEMETAP1METAP2 | |
| SCHEMBL10061944 | 0.78 | KDM4E (0.66) | HPSE | |
| SCHEMBL3925926 | 0.78 | AURKA (0.68) | AURKAPRMT5HPSEMETAP1METAP2 | |
| SCHEMBL1284270 | 0.77 | AURKA (0.73) | AURKAPRMT5HPSEMETAP1METAP2 | |
| SCHEMBL6265481 | 0.76 | AURKA (0.68) | AURKAPRMT5HPSEMETAP1METAP2 | |
| SCHEMBL28693174 | 0.76 | AURKA (0.68) | AURKAPRMT5HPSEMETAP1METAP2 | |
| SCHEMBL11770396 | 0.76 | AURKA (0.70) | AURKAPRMT5HPSEMETAP1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |