Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270959 | 0.87 | PDE2A (0.58) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL9635694 | 0.86 | PDE5A (0.51) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7272531 | 0.86 | PDE2A (0.57) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL9634292 | 0.84 | PDE5A (0.49) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL9635076 | 0.83 | PDE5A (0.48) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL10744182 | 0.82 | PDE5A (0.52) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL10847776 | 0.82 | PDE5A (0.54) | PDE5APDE3BPDE3AALDH1A1HPGD | |
| SCHEMBL7281375 | 0.82 | PDE5A (0.51) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL7282149 | 0.81 | CDK4 (0.56) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL9634814 | 0.81 | ADORA2B (0.48) | PDE5APDE3BPDE3APDE2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |