Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | STAT6 | P42226 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5112584 | 0.86 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL5112578 | 0.86 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL29048164 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL3932072 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL6216047 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL3932081 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL9634928 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL22426264 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL22426232 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL22426231 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310854-B1 | PROCESS FOR THE MANUFACTURE OF 3-AMINO-1-BENZYL-PYRROLIDINES | BAYER AG (DE) | 1992-05-20 | — | — | EP | disclosed |
| US-4910319-A | Process for preparing 3-amino-1-benzylpyrrolidines | BAYER AKTIENGESELLSCHAFT (DE) | 1990-03-20 | — | — | US | disclosed |
| EP-0310854-A1 | Process for the manufacture of 3-amino-1-benzyl-pyrrolidines | BAYER AG (DE) | 1989-04-12 | — | — | EP | disclosed |