Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 8/20 | 0.54 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15936060 | 0.83 | ALDH1A1 (0.58) | RYR2KDM1AALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL6867057 | 0.80 | RYR2 (0.51) | RYR2KCNH2SIGMAR1 | |
| SCHEMBL13622141 | 0.80 | RYR2 (0.55) | RYR2NOTUMKCNH2ALDH1A1 | |
| SCHEMBL14862467 | 0.79 | RYR2 (0.50) | RYR2KDM1ANOTUMKCNH2ALDH1A1 | |
| SCHEMBL13622143 | 0.78 | RYR2 (0.60) | RYR2NOTUMKCNH2ALDH1A1 | |
| SCHEMBL2062177 | 0.78 | RYR2 (0.41) | RYR2 | |
| SCHEMBL8248175 | 0.77 | RYR2 (0.57) | RYR2KDM1ANOTUMKCNH2CYP2D6 | |
| SCHEMBL15936312 | 0.76 | RYR2 (0.51) | RYR2NOTUMKCNH2SIGMAR1 | |
| SCHEMBL15935957 | 0.76 | DRD4 (0.51) | RYR2KCNH2ALDH1A1SIGMAR1 | |
| SCHEMBL7558332 | 0.76 | RYR2 (0.53) | RYR2NOTUMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2764867-A1 | Agents for preventing and treating disorders Involving modulation of the RYR receptors | The Trustees of Columbia University in the City of New York (US) | 2014-08-13 | — | — | EP | claimed |
| EP-0368063-B1 | PROCESS FOR THE CHLORINATION IN THE NUCLEUS OF AROMATIC HYDROCARBONS | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |
| US-4990707-A | Process for the ring chlorination of aromatic hydrocarbons | BAYER AKTIENGESELLSCHAFT (DE) | 1991-02-05 | — | — | US | disclosed |
| EP-0368063-A1 | Process for the chlorination in the nucleus of aromatic hydrocarbons | BAYER AG (DE) | 1990-05-16 | — | — | EP | disclosed |