Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 8/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636604 | 0.79 | RYR2 (0.54) | RYR2KCNH2NOTUMSIGMAR1ALDH1A1 | |
| SCHEMBL13622143 | 0.77 | RYR2 (0.60) | RYR2KCNH2NOTUMALDH1A1MAPT | |
| SCHEMBL7559424 | 0.77 | RYR2 (0.55) | RYR2KCNH2NOTUMKDM4E | |
| SCHEMBL6867057 | 0.76 | RYR2 (0.51) | RYR2KCNH2SIGMAR1 | |
| SCHEMBL13622141 | 0.76 | RYR2 (0.55) | RYR2KCNH2NOTUMALDH1A1KDM4E | |
| SCHEMBL15936312 | 0.76 | RYR2 (0.51) | RYR2KCNH2NOTUMSIGMAR1HDAC1 | |
| SCHEMBL2557765 | 0.75 | ADRA1D (0.52) | KCNH2ADRA1DADRA1AADRA1BNOTUM | |
| SCHEMBL1193519 | 0.75 | HDAC3 (0.54) | HDAC3HDAC1HDAC8NCOR2ALDH1A1 | |
| SCHEMBL15935957 | 0.73 | DRD4 (0.51) | RYR2KCNH2SIGMAR1ALDH1A1KDM4E | |
| SCHEMBL15936060 | 0.73 | ALDH1A1 (0.58) | RYR2SIGMAR1ALDH1A1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766370-A1 | COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| WO-2013053658-A1 | COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-18 | — | — | WO | disclosed |