Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.31 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28311753 | 0.98 | PTGS1 (0.38) | GRM2PTGS1PTGS2MGLLFAAH | |
| SCHEMBL29148766 | 0.98 | PTGS1 (0.38) | GRM2PTGS1PTGS2MGLLFAAH | |
| Bromide SCHEMBL28163104 | 0.97 | PTGS1 (0.37) | GRM2PTGS1PTGS2MGLLFAAH | |
| SCHEMBL28139190 | 0.95 | GRM2 (0.39) | GRM2 | |
| SCHEMBL27860597 | 0.80 | MGLL (0.36) | GRM2PTGS1PTGS2MGLLFAAH | |
| SCHEMBL11291370 | 0.80 | PTGS1 (0.40) | GRM2PTGS1PTGS2MGLLFAAH | |
| SCHEMBL28139836 | 0.79 | — | — | |
| SCHEMBL4949042 | 0.79 | GRM2 (0.36) | GRM2PTGS1PTGS2MGLLFAAH | |
| SCHEMBL27696873 | 0.79 | MGLL (0.39) | GRM2PTGS1PTGS2MGLLFAAH | |
| SCHEMBL27754562 | 0.79 | MGLL (0.39) | GRM2PTGS1PTGS2MGLLFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162338-A | For improving myocardial contractility; hypertensive agents, reducing mucosal swelling; salt and fluid balance | BAYER AKTIENGESELLSCHAFT (DE) | 1992-11-10 | — | — | US | claimed |
| EP-0231511-B1 | 4-AMINOARYLDIHYDROPYRIDINE LACTONES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AG (DE) | 1991-04-10 | — | — | EP | claimed |
| US-4804667-A | CARDIOTONIC, INOTROPIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-14 | — | — | US | claimed |
| EP-0231511-A1 | 4-Aminoaryldihydropyridine lactones, process for their preparation and their use in medicaments | BAYER AG (DE) | 1987-08-12 | — | — | EP | claimed |
| US-5162338-A | For improving myocardial contractility; hypertensive agents, reducing mucosal swelling; salt and fluid balance | BAYER AKTIENGESELLSCHAFT (DE) | 1992-11-10 | — | — | US | disclosed |
| EP-0231511-B1 | 4-AMINOARYLDIHYDROPYRIDINE LACTONES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AG (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4804667-A | CARDIOTONIC, INOTROPIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-14 | — | — | US | disclosed |
| US-4804667-A | CARDIOTONIC, INOTROPIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-14 | — | — | US | disclosed |
| EP-0231511-A1 | 4-Aminoaryldihydropyridine lactones, process for their preparation and their use in medicaments | BAYER AG (DE) | 1987-08-12 | — | — | EP | disclosed |
| EP-0231511-A1 | 4-Aminoaryldihydropyridine lactones, process for their preparation and their use in medicaments | BAYER AG (DE) | 1987-08-12 | — | — | EP | disclosed |
| EP-0231511-A1 | 4-Aminoaryldihydropyridine lactones, process for their preparation and their use in medicaments | BAYER AG (DE) | 1987-08-12 | — | — | EP | disclosed |