Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
| ▸ | AGXT | P21549 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6120599 | 0.83 | TSHR (0.45) | TSHRTACR1TDP1L3MBTL1HRH4 | |
| SCHEMBL7312276 | 0.83 | TSHR (0.45) | TSHRTACR1TDP1L3MBTL1HRH4 | |
| SCHEMBL6120254 | 0.83 | TSHR (0.45) | TSHRTACR1TDP1L3MBTL1HRH4 | |
| SCHEMBL17747743 | 0.80 | LTA4H (0.48) | TSHRSLC1A1HTTSMN1; SMN2 | |
| SCHEMBL17747744 | 0.80 | LTA4H (0.48) | TSHRSLC1A1HTTSMN1; SMN2 | |
| SCHEMBL1923485 | 0.77 | TSHR (0.45) | TSHRTACR1TDP1L3MBTL1EPHX1 | |
| SCHEMBL25467792 | 0.76 | TSHR (0.58) | TSHRTDP1L3MBTL1HRH4HRH3 | |
| SCHEMBL8768910 | 0.75 | SLC1A1 (0.57) | TDP1SLC1A1HTTSMN1; SMN2 | |
| SCHEMBL8618292 | 0.75 | SLC1A1 (0.57) | TDP1SLC1A1HTTSMN1; SMN2 | |
| SCHEMBL2640223 | 0.75 | TSHR (0.70) | TSHRTDP1L3MBTL1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0326766-B1 | 5-SUBSTITUTED ORNITHINE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4902719-A | ORNITHINE DEFICIENCY TREATMENT | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0326766-A1 | 5-Substituted ornithine derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-09 | — | — | EP | disclosed |