Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.41 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.41 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.41 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963792 | 1.00 | GPR119 (0.46) | GPR119DPP4ALDH1A1MAPTNPC1 | |
| SCHEMBL963589 | 0.88 | GPR119 (0.43) | GPR119DPP4ALDH1A1MAPTEED | |
| SCHEMBL15241131 | 0.88 | GPR119 (0.43) | GPR119DPP4ALDH1A1MAPTEED | |
| SCHEMBL1280096 | 0.88 | GPR119 (0.43) | GPR119DPP4ALDH1A1MAPTEED | |
| SCHEMBL1280097 | 0.88 | GPR119 (0.43) | GPR119DPP4ALDH1A1MAPTEED | |
| SCHEMBL1689421 | 0.88 | GPR119 (0.43) | GPR119DPP4ALDH1A1MAPTEED | |
| SCHEMBL963590 | 0.88 | GPR119 (0.43) | GPR119DPP4ALDH1A1MAPTEED | |
| SCHEMBL964465 | 0.86 | GPR119 (0.42) | GPR119DPP4ALDH1A1MAPTEED | |
| SCHEMBL964467 | 0.86 | GPR119 (0.42) | GPR119DPP4ALDH1A1MAPTEED | |
| SCHEMBL1054993 | 0.84 | GPR119 (0.46) | GPR119DPP4ALDH1A1MAPTEED |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853255-B2 | 3-phenoxymethylpyrrolidine compounds | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2456436-B1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE INC (US) | 2014-06-25 | — | — | EP | disclosed |
| US-20130237581-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2013-09-12 | — | — | US | disclosed |
| US-8455665-B2 | 3-phenoxymethylpyrrolidine compounds | THERAVANCE, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20120309985-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2012-12-06 | — | — | US | disclosed |
| US-8273786-B2 | 3-phenoxymethylpyrrolidine compounds | THERAVANCE, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-20110021597-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021597-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | HTR6, SLC6A4, SLC6A2 | GPR119 1219/4885DPP4 1381/4885ALDH1A1 580/4885 |
| US-20130237581-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | HTR6, SLC6A4, SLC6A2 | GPR119 1219/4885DPP4 1381/4885ALDH1A1 580/4885 |
| US-20120309985-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | HTR6, SLC6A4, SLC6A2 | GPR119 1219/4885DPP4 1381/4885ALDH1A1 580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.