Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.31 |
| ▸ | DUT | P33316 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1488779 | 0.88 | KMT2A (0.43) | DGAT1ALDH1A1POLBKMT2A | |
| SCHEMBL7843607 | 0.86 | ESR1 (0.47) | DGAT1EGFRIGF1RSRCFLT4 | |
| SCHEMBL1441203 | 0.85 | DGAT1 (0.46) | DGAT1 | |
| SCHEMBL2153326 | 0.85 | DGAT1 (0.40) | DGAT1ADRA2AADRA2BADRA2CEGFR | |
| SCHEMBL15986207 | 0.84 | DGAT1 (0.37) | DGAT1ALDH1A1PDE10A | |
| SCHEMBL9638951 | 0.84 | DGAT1 (0.65) | DGAT1ADRA2AADRA2BADRA2CPDE10A | |
| Hydrochloric Acid SCHEMBL15455783 | 0.83 | DGAT1 (0.37) | DGAT1 | |
| SCHEMBL3574886 | 0.83 | DGAT1 (0.42) | DGAT1DUTEGFRIGF1RSRC | |
| SCHEMBL1126106 | 0.83 | TLR8 (0.47) | DGAT1ALDH1A1POLBKMT2A | |
| SCHEMBL17810435 | 0.83 | DGAT1 (0.37) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147863-A | 2,2'-bi-1H-imidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-15 | — | — | US | disclosed |
| EP-0229922-B1 | NOVEL 2,2'-BI-1H-IMIDAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| EP-0229922-A2 | Novel 2,2'-BI-1H-imidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-07-29 | — | — | EP | disclosed |