Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 14/20 | 0.65 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9638271 | 0.84 | DGAT1 (0.41) | DGAT1PDE10AADRA2AADRA2BADRA2C | |
| SCHEMBL9638254 | 0.82 | DGAT1 (0.74) | DGAT1PDE10A | |
| SCHEMBL15293924 | 0.80 | DGAT1 (0.71) | DGAT1 | |
| SCHEMBL9936783 | 0.79 | DGAT1 (0.77) | DGAT1 | |
| SCHEMBL9940291 | 0.79 | DGAT1 (1.00) | DGAT1 | |
| SCHEMBL16787746 | 0.78 | DGAT1 (0.78) | DGAT1 | |
| SCHEMBL26094076 | 0.78 | DGAT1 (0.58) | DGAT1PDE10A | |
| SCHEMBL20302032 | 0.78 | DGAT1 (0.65) | DGAT1PDE10A | |
| SCHEMBL25249789 | 0.77 | DGAT1 (0.71) | DGAT1 | |
| SCHEMBL22143174 | 0.77 | DGAT1 (0.67) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147863-A | 2,2'-bi-1H-imidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-15 | — | — | US | disclosed |
| EP-0229922-B1 | NOVEL 2,2'-BI-1H-IMIDAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| EP-0229922-A2 | Novel 2,2'-BI-1H-imidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-07-29 | — | — | EP | disclosed |