Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | FOS | P01100 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8492602 | 0.79 | CYP4F2 (0.36) | LMNATSHRDHODHKDM4EHSD17B10 | |
| SCHEMBL3884597 | 0.77 | TSHR (0.50) | LMNATSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL14648620 | 0.77 | DHODH (0.43) | LMNADHODHMAPTPDE2A | |
| SCHEMBL27513121 | 0.77 | DHODH (0.46) | LMNADHODHMAPTPDE2A | |
| SCHEMBL26987310 | 0.76 | TSHR (0.48) | TSHRKDM4EHSD17B10ALDH1A1MEN1 | |
| SCHEMBL1027062 | 0.75 | DHODH (0.44) | LMNADHODHKDM4EALDH1A1KMT2A | |
| SCHEMBL15856620 | 0.74 | TSHR (0.47) | TSHRDHODHKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3541912 | 0.74 | KDM4E (0.49) | LMNATSHRDHODHKDM4EHSD17B10 | |
| SCHEMBL3067139 | 0.74 | DHODH (0.43) | LMNADHODHPDE2A | |
| SCHEMBL9639005 | 0.73 | DHODH (0.44) | LMNADHODHPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111971286-B | Substituted pyrrolo [2,3-d ] pyrimidine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2023-04-14 | — | — | CN | disclosed |
| CN-110177783-A | Hormone receptor modulators for the treatment of metabolic conditions and disorders | 阿德利克斯股份有限公司 | 2019-08-27 | — | — | CN | disclosed |
| EP-0326107-B1 | ANTIARTHRITIC BETA-CYCLOALKYL-BETA-OXOPROPIONITRILES | Bristol-Myers Squibb Company (US) | 1992-09-02 | — | — | EP | disclosed |
| US-4935434-A | Antiarthritic isoxazole-4-carboxamides | BRISTOL-MYERS COMPANY (US) | 1990-06-19 | — | — | US | disclosed |
| US-4888357-A | ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS COMPANY (US) | 1989-12-19 | — | — | US | disclosed |
| EP-0326107-A1 | Antiarthritic beta-cycloalkyl-beta-oxopropionitriles | Bristol-Myers Squibb Company (US) | 1989-08-02 | — | — | EP | disclosed |
| EP-0326108-A1 | Antiarthritic isoxazole-4-carboxamides | Bristol-Myers Company (US) | 1989-08-02 | — | — | EP | disclosed |