SCHEMBL9639005

SCHEMBL9639005

CNC(=O)c1cnoc1C1CC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 4/20 0.44
LMNA P02545 2/20 0.43
NAALAD2 Q9Y3Q0 1/20 0.40
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38
TAS1R2 Q8TE23 1/20 0.38
PDE2A O00408 1/20 0.37
EPHX2 P34913 2/20 0.36
CRACR2A Q9BSW2 3/20 0.36
KAT2B Q92831 1/20 0.36
BAZ2B Q9UIF8 1/20 0.36
NAMPT P43490 1/20 0.35
NPC1 O15118 1/20 0.35
GMNN O75496 1/20 0.35
TP53 P04637 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
HTR1A P08908 1/20 0.35
THRB P10828 1/20 0.35
PIM1 P11309 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1027062 0.82 DHODH (0.44) DHODHLMNANAALAD2TAS1R3TAS1R1
SCHEMBL9638659 0.82 LMNA (0.56) DHODHLMNANAALAD2TAS1R3TAS1R1
SCHEMBL14648620 0.81 DHODH (0.43) DHODHLMNANAALAD2TAS1R3TAS1R1
SCHEMBL9639001 0.81 LMNA (0.62) DHODHLMNANAALAD2TAS1R3TAS1R1
SCHEMBL27513121 0.80 DHODH (0.46) DHODHLMNANAALAD2TAS1R3TAS1R1
SCHEMBL10424090 0.79 DHODH (0.41) DHODHLMNANAALAD2TAS1R3TAS1R1
SCHEMBL3067139 0.77 DHODH (0.43) DHODHLMNANAALAD2TAS1R3TAS1R1
SCHEMBL8941898 0.75 DHODH (0.41) DHODHLMNANAALAD2TAS1R3TAS1R1
SCHEMBL27606823 0.74 CYP2C8 (0.42) DHODHLMNANPC1CYP3A4CYP2C9
SCHEMBL8045714 0.73 RAB9A (0.47) DHODHLMNACRACR2ANPC1GMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4935434-A Antiarthritic isoxazole-4-carboxamides BRISTOL-MYERS COMPANY (US) 1990-06-19 US claimed
EP-0326108-A1 Antiarthritic isoxazole-4-carboxamides Bristol-Myers Company (US) 1989-08-02 EP claimed
EP-0326107-B1 ANTIARTHRITIC BETA-CYCLOALKYL-BETA-OXOPROPIONITRILES Bristol-Myers Squibb Company (US) 1992-09-02 EP disclosed
US-4935434-A Antiarthritic isoxazole-4-carboxamides BRISTOL-MYERS COMPANY (US) 1990-06-19 US disclosed
US-4888357-A ANTIINFLAMMATORY AGENTS BRISTOL-MYERS COMPANY (US) 1989-12-19 US disclosed
EP-0326107-A1 Antiarthritic beta-cycloalkyl-beta-oxopropionitriles Bristol-Myers Squibb Company (US) 1989-08-02 EP disclosed