Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600881 | 0.79 | TLR8 (0.69) | SMN1; SMN2HTTCYP2D6CYP2C19NPC1 | |
| SCHEMBL26079933 | 0.76 | EPHX1 (0.47) | SMN1; SMN2HTTATMEPHX2NPC1 | |
| SCHEMBL15942896 | 0.76 | CYP2D6 (0.51) | SMN1; SMN2ATMCYP2D6CYP2C19MAPT | |
| SCHEMBL11752857 | 0.75 | CYP2D6 (0.64) | SMN1; SMN2CYP2D6CYP2C19TLR8MAPT | |
| SCHEMBL10988809 | 0.74 | MAPT (0.51) | SMN1; SMN2ATMCYP2D6CYP2C19MAPT | |
| SCHEMBL7135338 | 0.74 | CYP2D6 (0.62) | SMN1; SMN2CYP2D6CYP2C19TLR8ALDH1A1 | |
| SCHEMBL7118699 | 0.74 | CYP2D6 (0.62) | SMN1; SMN2CYP2D6CYP2C19TLR8ALDH1A1 | |
| SCHEMBL7117794 | 0.74 | CYP2D6 (0.62) | SMN1; SMN2CYP2D6CYP2C19TLR8ALDH1A1 | |
| SCHEMBL7124897 | 0.74 | CYP2D6 (0.62) | SMN1; SMN2CYP2D6CYP2C19TLR8ALDH1A1 | |
| SCHEMBL16703349 | 0.74 | CYP2D6 (0.62) | SMN1; SMN2CYP2D6CYP2C19TLR8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126453-A | Chemical intermediate for Minoxidil | L'OREAL (FR) | 1992-06-30 | — | — | US | disclosed |
| US-5034387-A | Applying to skins for hair growth and skin disorders | L'OREAL (FR) | 1991-07-23 | — | — | US | disclosed |
| US-4985563-A | Hypotensive Agent; Reacting a Diaminopyrimidine with an Isocyanate, oxidation | L'OREAL (FR) | 1991-01-15 | — | — | US | disclosed |
| US-4945093-A | SKIN DISORDERS, HAIR LOSS | L'OREAL (FR) | 1990-07-31 | — | — | US | disclosed |