Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15942896 | 0.84 | CYP2D6 (0.51) | MAPTSMN1; SMN2GAAPOLBCYP2D6 | |
| SCHEMBL3804329 | 0.84 | HSP90AA1 (0.47) | MAPTSMN1; SMN2GAAPOLBCYP2D6 | |
| SCHEMBL10851267 | 0.82 | S1PR2 (0.41) | SMN1; SMN2LMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL28229830 | 0.78 | SMN1; SMN2 (0.61) | MAPTSMN1; SMN2GAAPOLBCYP2D6 | |
| SCHEMBL13327841 | 0.78 | PKM (0.42) | MAPTSMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL28861390 | 0.76 | RXFP1 (0.61) | MAPTSMN1; SMN2GAALMNAKMT2A | |
| SCHEMBL28229168 | 0.75 | GRM5 (0.60) | MAPTSMN1; SMN2GAAPOLBKMT2A | |
| SCHEMBL4098854 | 0.75 | CYP2D6 (0.53) | MAPTSMN1; SMN2GAAPOLBCYP2D6 | |
| SCHEMBL13322077 | 0.75 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2GAAPOLBCYP2D6 | |
| SCHEMBL9638923 | 0.74 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2POLBCYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4549019-A | Pyrimidinecarbamate derivatives as intermediates | HOFFMANN-LA ROCHE INC. (US) | 1985-10-22 | — | — | US | disclosed |