SCHEMBL963902

SCHEMBL963902

NC(=O)CNCCc1ccc(OCc2ccccc2F)cc1

nearest known ligand 0.78

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SCN3A Q9NY46 7/20 0.78
MAOB P27338 5/20 0.60
PARP15 Q460N3 2/20 0.59
PARP10 Q53GL7 2/20 0.59
PARP14 Q460N5 1/20 0.59
SCN9A Q15858 2/20 0.57
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
LPAR1 Q92633 1/20 0.48
LPAR5 Q9H1C0 1/20 0.48
KCNH2 Q12809 3/20 0.47
SCN1A P35498 1/20 0.47
SCN4A P35499 1/20 0.47
SCN7A Q01118 1/20 0.47
SCN5A Q14524 1/20 0.47
SCN2A Q99250 1/20 0.47
SCN8A Q9UQD0 1/20 0.47
SCN10A Q9Y5Y9 1/20 0.47
PTPN1 P18031 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL964219 0.88 SCN3A (1.00) SCN3AMAOBPARP15PARP10PARP14
SCHEMBL963385 0.87 SCN3A (0.63) SCN3AMAOBPARP15PARP10PARP14
SCHEMBL87713 0.85 MAOB (0.59) SCN3AMAOBMEN1KMT2A
SCHEMBL68789 0.83 BCHE (0.65) PARP10MEN1KMT2A
SCHEMBL4453247 0.83 SCN3A (0.57) SCN3AMAOBPARP15PARP10PARP14
SCHEMBL5418264 0.81 SCN3A (0.78) SCN3AMAOBPARP15PARP10PARP14
SCHEMBL964122 0.80 SCN9A (0.79) SCN3AMAOBPARP15PARP10PARP14
SCHEMBL965290 0.80 MAOB (0.62) MAOBPARP10SCN9A
SCHEMBL963826 0.77 SCN3A (0.76) SCN3AMAOBPARP15PARP10PARP14
SCHEMBL28570332 0.77 FFAR1 (0.71) MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2222290-B1 ALPHA-AMINOAMIDE DERIVATIVES FOR THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARM SPA (IT) 2021-06-16 EP claimed
US-8445539-B2 Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders NEWRON PHARMACEUTICALS S.P.A. (IT) 2013-05-21 US claimed
US-20110014304-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2011-01-20 US claimed
EP-2222290-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS Newron Pharmaceuticals S.p.A. (IT) 2010-09-01 EP claimed
WO-2009080470-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2009-07-02 WO claimed
EP-2222290-B1 ALPHA-AMINOAMIDE DERIVATIVES FOR THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARM SPA (IT) 2021-06-16 EP disclosed
US-8445539-B2 Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders NEWRON PHARMACEUTICALS S.P.A. (IT) 2013-05-21 US disclosed
US-20110014304-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2011-01-20 US disclosed
EP-2222290-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS Newron Pharmaceuticals S.p.A. (IT) 2010-09-01 EP disclosed
WO-2009080470-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2009-07-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110014304-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS GABBR1, GABBR2, GABRA5 SCN3A 803/4885MAOB 60/4885PARP15 3976/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.