Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.51 |
| ▸ | DHFR | P00374 | 2/20 | 0.50 |
| ▸ | SORD | Q00796 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8981923 | 0.81 | KDM4E (0.60) | KDM4EMAPTALDH1A1HSD17B10POLB | |
| SCHEMBL29857922 | 0.80 | PLD1 (0.73) | KDM4EMAPTALDH1A1HSD17B10POLB | |
| SCHEMBL15800694 | 0.80 | PLD1 (0.73) | KDM4EMAPTALDH1A1HSD17B10POLB | |
| SCHEMBL21353591 | 0.80 | — | — | |
| SCHEMBL8957707 | 0.80 | LMNA (0.47) | KDM4EMAPTALDH1A1NPC1GAA | |
| SCHEMBL3867807 | 0.78 | KDM4E (0.64) | KDM4EMAPTALDH1A1HSD17B10POLB | |
| SCHEMBL18893549 | 0.77 | KDM4E (0.59) | KDM4EMAPTALDH1A1HSD17B10POLB | |
| SCHEMBL159733 | 0.75 | PLD1 (0.61) | KDM4EMAPTALDH1A1HSD17B10POLB | |
| SCHEMBL29904791 | 0.75 | PLD1 (0.61) | KDM4EMAPTALDH1A1HSD17B10POLB | |
| SCHEMBL5518001 | 0.75 | KDM4E (0.60) | KDM4EMAPTALDH1A1HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496746-A1 | PHARMACEUTICALLY ACTIVE AMINO-SUBSTITUTED HETEROARYL AMINES | THE UPJOHN COMPANY (US) | 1992-08-05 | — | — | EP | disclosed |
| WO-1991006542-A1 | PHARMACEUTICALLY ACTIVE AMINO-SUBSTITUTED HETEROARYL AMINES | THE UPJOHN COMPANY (US) | 1991-05-16 | — | — | WO | disclosed |