SCHEMBL9640335

SCHEMBL9640335

COC1=CC(=O)OC1C(OC(=O)[C@@H]1CCCN1)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.45
CYP2D6 P10635 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2C19 P33261 1/20 0.45
TSHR P16473 2/20 0.42
CYP2C9 P11712 1/20 0.42
ELANE P08246 1/20 0.40
SLC6A3 Q01959 5/20 0.39
SLC6A2 P23975 3/20 0.39
SLC6A4 P31645 2/20 0.39
DHFR P00374 1/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
KDM4E B2RXH2 1/20 0.37
DPP4 P27487 2/20 0.35
DPP8 Q6V1X1 1/20 0.35
TACR1 P25103 1/20 0.35
ANPEP P15144 1/20 0.35
CTSC P53634 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9639322 0.88 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19TSHR
Bromide SCHEMBL10393939 0.88 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19TSHR
SCHEMBL9640466 0.87 CYP3A4 (0.37) CYP3A4CYP2D6CYP1A2CYP2C19TSHR
SCHEMBL9639485 0.86 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19TSHR
SCHEMBL9640340 0.86 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19TSHR
Hydrochloric Acid SCHEMBL10394208 0.85 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19TSHR
Bromide SCHEMBL10393773 0.85 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19TSHR
Bromide SCHEMBL10393772 0.85 CYP3A4 (0.36) CYP3A4CYP2D6CYP1A2CYP2C19TSHR
SCHEMBL9639488 0.85 CYP1A2 (0.35) CYP3A4CYP2D6CYP1A2CYP2C19TSHR
Bromide SCHEMBL10394849 0.84 CYP1A2 (0.35) CYP3A4CYP2D6CYP1A2CYP2C19TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0349609-B1 AMINOACID ESTERS, PROCESS FOR THEIR MANUFACTURE AND THEIR USE Dr. Willmar Schwabe GmbH & Co. (DE) 1992-08-05 EP disclosed
EP-0349609-A1 AMINOACID ESTERS, PROCESS FOR THEIR MANUFACTURE AND THEIR USE Dr. Willmar Schwabe GmbH & Co. (DE) 1990-01-10 EP disclosed
WO-1989004310-A1 AMINOACID ESTERS, PROCESS FOR THEIR MANUFACTURE AND THEIR USE DR. WILLMAR SCHWABE GMBH & CO. (DE) 1989-05-18 WO disclosed