Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.55 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.55 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641050 | 0.99 | TP53 (0.64) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL9641162 | 0.89 | TP53 (0.57) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL9640319 | 0.89 | SOAT1 (0.68) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL9640371 | 0.88 | SOAT1 (0.67) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL9640344 | 0.88 | TP53 (0.56) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL9641110 | 0.85 | LMNA (0.57) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL9818610 | 0.85 | TP53 (0.79) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL9640346 | 0.84 | LMNA (0.56) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL9200734 | 0.83 | SOAT1 (0.77) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL9641246 | 0.82 | SOAT1 (0.76) | TP53LMNASMN1; SMN2L3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | claimed |
| EP-0293880-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC UREA COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1992-08-26 | — | — | EP | disclosed |
| US-5015644-A | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds | WARNER-LAMBERT COMPANY (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0293880-A1 | Antihyperlipidemic and antiatherosclerotic urea compounds | WARNER-LAMBERT COMPANY (US) | 1988-12-07 | — | — | EP | disclosed |