Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291664 | 0.78 | GAA (0.41) | GAARXFP1PPARGNCOR2LMNA | |
| SCHEMBL7291463 | 0.78 | GAA (0.41) | GAARXFP1PPARGNCOR2LMNA | |
| SCHEMBL7281825 | 0.78 | GAA (0.41) | GAARXFP1PPARGNCOR2LMNA | |
| SCHEMBL7291641 | 0.76 | PKM (0.40) | GAARXFP1PPARGNCOR2LMNA | |
| SCHEMBL7289327 | 0.74 | KDM4E (0.44) | GAARXFP1PPARGNCOR2KMT2A | |
| SCHEMBL10466353 | 0.71 | GAA (1.00) | GAARXFP1PPARGNCOR2LMNA | |
| SCHEMBL7335306 | 0.70 | GAA (0.42) | GAAKDM4EALDH1A1ATMPDE4A | |
| SCHEMBL7335311 | 0.70 | GAA (0.46) | GAAKMT2AMEN1TSHRKDM4E | |
| SCHEMBL9640574 | 0.68 | GAA (0.47) | GAARXFP1PPARGNCOR2LMNA | |
| SCHEMBL7282267 | 0.68 | GAA (0.41) | GAALMNAKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4505910-A | Amino-pyrimidine derivatives, compositions and use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-03-19 | — | — | US | disclosed |
| EP-0130735-A1 | Amino-pyrimidine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-01-09 | — | — | EP | disclosed |