Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657072 | 0.80 | LMNA (0.35) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL6664071 | 0.73 | PTPN1 (0.35) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL12043327 | 0.70 | CHRM2 (0.56) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9594622 | 0.70 | CHRM2 (0.56) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9594847 | 0.70 | CHRM2 (0.37) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9594965 | 0.68 | LMNA (0.44) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2420231 | 0.68 | CHRM3 (0.58) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9594492 | 0.66 | SIGMAR1 (0.41) | LMNABLMCYP1A2CYP2D6PMP22 | |
| SCHEMBL9384325 | 0.65 | LMNA (0.39) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9594515 | 0.63 | CHRM2 (0.50) | CHRM2CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288394-B1 | 1,2,5,6-TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-09-09 | — | — | EP | disclosed |