Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 8/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641120 | 0.85 | KMT2A (0.48) | ALOX5FFAR1ALDH1A1 | |
| SCHEMBL6904351 | 0.83 | FFAR1 (0.61) | ALOX5FFAR1LTB4RLTB4R2S1PR5 | |
| SCHEMBL3984108 | 0.81 | TDP1 (0.48) | ALDH1A1KCNH2ACP3 | |
| SCHEMBL3044206 | 0.81 | TDP1 (0.48) | ALDH1A1KCNH2ACP3 | |
| SCHEMBL3984623 | 0.81 | TDP1 (0.48) | ALDH1A1KCNH2ACP3 | |
| SCHEMBL9642280 | 0.81 | ACACB (0.65) | ALOX5FFAR1LTB4RLTB4R2 | |
| SCHEMBL14268020 | 0.80 | ALOX5 (0.55) | ALOX5FFAR1LTB4RLTB4R2S1PR5 | |
| SCHEMBL4363303 | 0.79 | FFAR1 (0.56) | ALOX5FFAR1LTB4RLTB4R2S1PR5 | |
| Hydrochloric Acid SCHEMBL8783045 | 0.79 | MEN1 (0.50) | ALDH1A1KCNH2ACP3 | |
| SCHEMBL10767870 | 0.78 | FFAR1 (0.57) | ALOX5FFAR1LTB4RLTB4R2S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279281-B1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-08-26 | — | — | EP | disclosed |
| US-5026729-A | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1991-06-25 | — | — | US | disclosed |
| US-4897422-A | TREATMENT OF ASTHMA, RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0279281-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1988-08-24 | — | — | EP | disclosed |