Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Ephedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.81 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.81 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.74 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.81 |
| ▸ | RGS12 | O14924 | 1/20 | 0.81 |
| ▸ | GLA | P06280 | 1/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.81 |
| ▸ | PKM | P14618 | 1/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
| ▸ | THPO | P40225 | 1/20 | 0.81 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pseudoephedrine SCHEMBL4780816 | 1.00 | ADRA2C (0.81) | ADRA2CADRA1AHTR2ACHRM2RGS12 | |
| Pseudoephedrine SCHEMBL282453 | 1.00 | ADRA2C (0.81) | ADRA2CADRA1AHTR2ACHRM2RGS12 | |
| Pseudoephedrine SCHEMBL9390910 | 0.98 | KMT2A (0.82) | ADRA2CADRA1AHTR2ACHRM2RGS12 | |
| Racephedrine SCHEMBL28739755 | 0.90 | ADRA2C (0.92) | ADRA2CADRA1AHTR2ACHRM2RGS12 | |
| Ephedrine SCHEMBL4731265 | 0.90 | CYP2D6 (1.00) | ADRA2CADRA1AHTR2ACHRM2RGS12 | |
| Racephedrine SCHEMBL11906521 | 0.90 | CYP2D6 (1.00) | ADRA2CADRA1AHTR2ACHRM2RGS12 | |
| Racephedrine SCHEMBL12573578 | 0.90 | CYP2D6 (1.00) | ADRA2CADRA1AHTR2ACHRM2RGS12 | |
| Racephedrine SCHEMBL8098202 | 0.90 | CYP2D6 (1.00) | ADRA2CADRA1AHTR2ACHRM2RGS12 | |
| Racephedrine SCHEMBL4786 | 0.90 | CYP2D6 (1.00) | ADRA2CADRA1AHTR2ACHRM2RGS12 | |
| Pseudoephedrine SCHEMBL4368 | 0.90 | CYP2D6 (1.00) | ADRA2CADRA1AHTR2ACHRM2RGS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5174998-A | Sustained release compositions using as matrix hemicellulose extracted from wheat bran | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-12-29 | — | — | US | disclosed |
| EP-0371493-B1 | SUSTAINED RELEASE COMPOSITIONS CONTAINING A HEMICELLULOSE MATRIX | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-09-23 | — | — | EP | disclosed |
| EP-0371493-A1 | Sustained release compositions containing a hemicellulose matrix | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-06-06 | — | — | EP | disclosed |