Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9642811 | 0.91 | ABCB11 (0.54) | ABCB11MRGPRX4LMNAHPGDMAPT | |
| SCHEMBL9643565 | 0.85 | ABCB11 (0.67) | ABCB11LMNAHPGDMAPTPOLB | |
| SCHEMBL9641822 | 0.82 | ABCB11 (0.46) | ABCB11MRGPRX4MAPTTDP1 | |
| SCHEMBL9642865 | 0.79 | ABCB11 (0.57) | ABCB11LMNAMAPTPOLBGAA | |
| SCHEMBL9642080 | 0.79 | ABCB11 (0.57) | ABCB11LMNAMAPTPOLBGAA | |
| SCHEMBL9644155 | 0.78 | ABCB11 (0.38) | ABCB11TP53LMNAHPGDMAPT | |
| SCHEMBL9642978 | 0.78 | ABCB11 (0.53) | ABCB11LMNAHPGDMAPT | |
| SCHEMBL9643065 | 0.78 | ABCB11 (0.53) | ABCB11LMNAHPGDMAPT | |
| SCHEMBL9641751 | 0.76 | HPGD (0.46) | TP53MRGPRX4HPGDMAPTMAOA | |
| SCHEMBL9643216 | 0.76 | MAPT (0.39) | ABCB11MRGPRX4LMNAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215622-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4946845-A | STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4792556-A | LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0215622-A2 | Naphthalene anti-psoriatic agents and process for making them | SYNTEX (U.S.A.) INC. (US) | 1987-03-25 | — | — | EP | disclosed |