Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | C5 | P01031 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9642523 | 0.95 | ABCB11 (0.52) | ABCB11NPSR1ALDH1A1L3MBTL1CRHBP | |
| SCHEMBL9641702 | 0.93 | ABCB11 (0.60) | ABCB11NPSR1ALDH1A1L3MBTL1CRHBP | |
| SCHEMBL9641621 | 0.85 | ABCB11 (0.59) | ABCB11PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9643541 | 0.84 | ABCB11 (0.51) | ABCB11NPSR1PSEN1PSEN2APH1B | |
| SCHEMBL9644111 | 0.84 | ABCB11 (0.51) | ABCB11NPSR1PSEN1PSEN2APH1B | |
| SCHEMBL9642080 | 0.81 | ABCB11 (0.57) | ABCB11ALDH1A1MAPTKMT2APDE4D | |
| SCHEMBL9643855 | 0.80 | ABCB11 (0.59) | ABCB11PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9643275 | 0.79 | ABCB11 (0.45) | ABCB11PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9641850 | 0.79 | ABCB11 (0.83) | ABCB11MAPTPDE4DTUBB4ATUBB | |
| SCHEMBL9642749 | 0.78 | ABCB11 (0.53) | ABCB11ALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215622-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4946845-A | STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4792556-A | LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |