Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 13/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11468007 | 0.83 | APP (0.64) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Ximoprofen SCHEMBL152469 | 0.82 | APP (0.46) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Ximoprofen SCHEMBL152468 | 0.82 | APP (0.46) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Ximoprofen SCHEMBL505729 | 0.82 | APP (0.46) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Hexaprofen SCHEMBL2111016 | 0.82 | APP (0.67) | PTGS1PTGS2OPRK1HTTKMT2A | |
| SCHEMBL2436189 | 0.80 | APP (0.56) | PTGS1PTGS2OPRK1HTTKMT2A | |
| SCHEMBL11428636 | 0.77 | APP (0.51) | PTGS1PTGS2APPMT-CO1MT-CO2 | |
| SCHEMBL7542404 | 0.77 | PTGS1 (0.60) | PTGS1PTGS2OPRK1HTTKMT2A | |
| SCHEMBL2313256 | 0.76 | ESR2 (0.49) | KMT2AESR2EPHX1 | |
| SCHEMBL18980594 | 0.76 | ESR2 (0.49) | KMT2AESR2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0362309-B1 | (ETHYLENEDIOXO-3,3 CYCLOHEXYL)-4 ACETOPHENONE AND DERIVATIVES THEREOF, PROCESSES FOR PREPARING THEM AND USE OF THESE COMPOUNDS | SOCHINAZ, SOCIETE CHIMIQUE DE VIONNAZ S.A. (CH) | 1992-09-23 | — | — | EP | claimed |
| US-5104995-A | Multistage reactions for preparing 2-(4-(3-oxocyclohexyl) phenyl) propionic acid | SOCHINAZ, SOCIETE CHIMIQUE DE VIOMAZ S.A. (CH) | 1992-04-14 | — | — | US | disclosed |
| US-3935255-A | Phenylacetic acid derivatives | LABORATOIRES JACQUES LOGEAIS (FR) | 1976-01-27 | — | — | US | disclosed |