Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 4/20 | 0.59 |
| ▸ | FAAH | O00519 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.56 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.52 |
| ▸ | STAT5B | P51692 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2183633 | 0.83 | MGLL (0.85) | MGLLFAAHALDH1A1TRPV1DAGLA | |
| SCHEMBL5274003 | 0.79 | TRPV1 (0.53) | MGLLFAAHALDH1A1TRPV1DAGLA | |
| SCHEMBL11456469 | 0.77 | KDM4C (0.62) | MGLLFAAHALDH1A1TRPV1DAGLA | |
| SCHEMBL1067246 | 0.77 | ALDH1A1 (0.46) | MGLLFAAHALDH1A1TRPV1DAGLA | |
| SCHEMBL28339490 | 0.77 | ALDH1A1 (0.46) | MGLLFAAHALDH1A1TRPV1DAGLA | |
| SCHEMBL2184828 | 0.75 | MGLL (1.00) | MGLLFAAHALDH1A1TRPV1DAGLA | |
| SCHEMBL2092704 | 0.74 | CNR2 (0.54) | MGLLFAAHALDH1A1TRPV1DAGLA | |
| SCHEMBL28099662 | 0.74 | CNR2 (0.54) | MGLLFAAHALDH1A1TRPV1DAGLA | |
| SCHEMBL17460204 | 0.74 | TRPV1 (0.61) | MGLLFAAHALDH1A1TRPV1 | |
| SCHEMBL28017015 | 0.73 | ALDH1A1 (0.44) | MGLLFAAHALDH1A1TRPV1DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303478-B1 | IMPROVEMENTS IN OR RELATING TO LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1992-09-30 | — | — | EP | disclosed |
| US-4820723-A | FOR TREATMENT OF HYPERSENSITIVITY, ASTHMA, SHOCK OR CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0303478-A1 | Improvements in or relating to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1989-02-15 | — | — | EP | disclosed |