Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 10/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9643282 | 0.95 | ABCB11 (0.52) | ABCB11GSK3BTRPV1ALOX15TOP2A | |
| SCHEMBL9642233 | 0.93 | ABCB11 (0.60) | ABCB11TRPV1ALOX15TOP2A | |
| SCHEMBL9643387 | 0.92 | ABCB11 (0.58) | ABCB11GSK3BALOX15 | |
| SCHEMBL9642103 | 0.87 | ABCB11 (0.58) | ABCB11GSK3BALOX15 | |
| SCHEMBL9642400 | 0.86 | ABCB11 (0.53) | ABCB11ALOX15TOP2A | |
| SCHEMBL9643002 | 0.86 | ABCB11 (0.53) | ABCB11ALOX15TOP2A | |
| SCHEMBL9643391 | 0.85 | ALOX15 (0.40) | ABCB11GSK3BALOX15 | |
| SCHEMBL9641664 | 0.85 | ABCB11 (0.52) | ABCB11TRPV1ALOX15TOP2A | |
| SCHEMBL9643146 | 0.85 | ABCB11 (0.52) | ABCB11TRPV1ALOX15TOP2A | |
| SCHEMBL9642632 | 0.85 | ABCB11 (0.59) | ABCB11ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215622-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4946845-A | STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4792556-A | LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0215622-A2 | Naphthalene anti-psoriatic agents and process for making them | SYNTEX (U.S.A.) INC. (US) | 1987-03-25 | — | — | EP | disclosed |