Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 6/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9643227 | 0.95 | ABCB11 (0.46) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9641905 | 0.93 | ABCB11 (0.53) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9643550 | 0.82 | ABCB11 (0.57) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9643340 | 0.82 | ABCB11 (0.43) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9713770 | 0.81 | HTT (0.44) | ABCB11IGLV6-57BACE1FFAR1LTB4R | |
| SCHEMBL9642983 | 0.78 | PDE4A (0.53) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9643309 | 0.77 | ABCB11 (0.44) | ABCB11BACE1FFAR1ALOX5 | |
| SCHEMBL9642480 | 0.77 | ABCB11 (0.57) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9642268 | 0.77 | ABCB11 (0.55) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9642660 | 0.74 | ABCB11 (0.57) | ABCB11PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215622-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4946845-A | STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4792556-A | LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |