Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 3/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10706974 | 0.90 | KDM4E (0.44) | KDM4EALDH1A1MAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL20398569 | 0.88 | ELANE (0.50) | KDM4EALDH1A1MAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL9643982 | 0.82 | L3MBTL1 (0.41) | KDM4EALDH1A1CYP1A2CYP2C9IDO1 | |
| SCHEMBL9642591 | 0.82 | L3MBTL1 (0.41) | KDM4EALDH1A1MAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL9642066 | 0.82 | ABCB11 (0.48) | KDM4EALDH1A1ELANEABCB11L3MBTL1 | |
| SCHEMBL9656750 | 0.81 | KDM4E (0.61) | KDM4EALDH1A1MAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL9627599 | 0.80 | HTT (0.44) | KDM4EALDH1A1SMN1; SMN2KLKB1ELANE | |
| SCHEMBL9642160 | 0.80 | ABCB11 (0.70) | ALDH1A1ELANEABCB11PDE4D | |
| SCHEMBL9643543 | 0.80 | ABCB11 (0.41) | ALDH1A1KLKB1ELANEABCB11L3MBTL1 | |
| SCHEMBL9643487 | 0.79 | L3MBTL1 (0.41) | KDM4EALDH1A1MAPK1SMN1; SMN2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215622-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4946845-A | STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4792556-A | LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0215622-A2 | Naphthalene anti-psoriatic agents and process for making them | SYNTEX (U.S.A.) INC. (US) | 1987-03-25 | — | — | EP | disclosed |
| US-4593120-A | Naphthalene-1,4-dicarboxylic acid group | SYNTEX (U.S.A.) INC. (US) | 1986-06-03 | — | — | US | disclosed |