Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | CRYAB | P02511 | 3/20 | 0.38 |
| ▸ | CRYAA | P02489 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 2/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9644065 | 1.00 | MAPT (0.45) | MAPTUSP2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9766738 | 0.86 | MAPT (0.40) | MAPTUSP2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9766733 | 0.86 | MAPT (0.40) | MAPTUSP2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9771470 | 0.85 | MAPT (0.39) | MAPTUSP2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9771465 | 0.85 | MAPT (0.39) | MAPTUSP2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9766769 | 0.84 | MAPT (0.48) | MAPTUSP2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9766774 | 0.84 | MAPT (0.48) | MAPTUSP2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9769622 | 0.83 | MAPT (0.47) | MAPTUSP2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9769618 | 0.81 | USP2 (0.40) | MAPTUSP2ALDH1A1CYP3A4ALOX15 | |
| SCHEMBL9769598 | 0.81 | USP2 (0.40) | MAPTUSP2ALDH1A1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276823-B1 | 14,15-SUBSTITUTED LANOSTEROLS AND THEIR USE AS HYPOCHOLESTEROLEMIC AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-09-23 | — | — | EP | disclosed |
| US-5041432-A | Enzyme inhibitors | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-08-20 | — | — | US | disclosed |
| US-5034548-A | Enzyme inhibitors for reducing serum cholesterol | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-07-23 | — | — | US | disclosed |
| EP-0276823-A2 | 14,15-Substituted lanosterols and their use as hypocholesterolemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1988-08-03 | — | — | EP | disclosed |