Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 3/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.36 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.36 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.36 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.34 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.34 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL947957 | 0.88 | RPS6KA2 (0.46) | ITKSCD5RPS6KA3RPS6KA2RPS6KA1 | |
| SCHEMBL951873 | 0.87 | KMT2A (0.44) | ITKSCD5RPS6KA3RPS6KA2RPS6KA1 | |
| SCHEMBL1002318 | 0.86 | CHEK1 (0.47) | CHEK1 | |
| SCHEMBL948561 | 0.85 | ITK (0.50) | ITKSCD5RPS6KA3RPS6KA2RPS6KA1 | |
| SCHEMBL948091 | 0.85 | ALDH1A1 (0.41) | SCD5RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL950898 | 0.85 | KLKB1 (0.45) | ITKRPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL951550 | 0.83 | KMT2A (0.40) | ITKRPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL949397 | 0.83 | KLKB1 (0.39) | ITKRPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL960971 | 0.82 | KLKB1 (0.32) | KDRMAPTTAS2R8 | |
| SCHEMBL949207 | 0.82 | SCD (0.44) | SCD5SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011010083-A1 | INDOLYL-PYRIDONE DERIVATIVES | VERNALIS (R & D) LTD (GB) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011010083-A1 | INDOLYL-PYRIDONE DERIVATIVES | VERNALIS (R & D) LTD (GB) | 2011-01-27 | — | — | WO | disclosed |