Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784638 | 0.85 | CYP1A2 (0.59) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL9844068 | 0.84 | PTGS2 (0.57) | SIRT1MAPTLMNAMEN1NR1I2 | |
| SCHEMBL11174329 | 0.84 | PTGS2 (0.57) | SIRT1MAPTLMNAMEN1NR1I2 | |
| SCHEMBL27453666 | 0.83 | PTGS2 (0.56) | SIRT1MAPTLMNAMEN1NR1I2 | |
| Iodide SCHEMBL8515613 | 0.83 | PTGS2 (0.56) | SIRT1MAPTLMNAMEN1NR1I2 | |
| SCHEMBL18010736 | 0.82 | PTGS2 (0.56) | SIRT1MAPTLMNAMEN1NR1I2 | |
| SCHEMBL6780943 | 0.79 | PTGS2 (0.53) | SIRT1MAPTLMNAMEN1NR1I2 | |
| SCHEMBL9038340 | 0.77 | TSHR (0.56) | MAPTLMNACYP3A4CYP1A2KDM4E | |
| SCHEMBL1013654 | 0.75 | HSD17B10 (0.62) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL6232914 | 0.75 | CYP1A2 (0.65) | MAPTLMNAMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322389-B1 | NOVEL ANTIARRHYTHMIC AGENTS II | Aktiebolaget Hässle (SE) | 1992-10-28 | — | — | EP | disclosed |
| US-5034411-A | Cardiovascular disorders or antiarrhythmia agents | AKTIEBOLAGET HASSLE (SE) | 1991-07-23 | — | — | US | disclosed |
| WO-1989005795-A1 | NOVEL ANTIARRHYTHMIC AGENTS II | Aktiebolaget Hässle (SE) | 1989-06-29 | — | — | WO | disclosed |