Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27453666 | 0.90 | PTGS2 (0.56) | PTGS2SIRT1KMT2AMAPTLMNA | |
| SCHEMBL18010736 | 0.88 | PTGS2 (0.56) | PTGS2SIRT1KMT2AMAPTLMNA | |
| SCHEMBL9844068 | 0.87 | PTGS2 (0.57) | PTGS2SIRT1KMT2AMAPTLMNA | |
| SCHEMBL11174329 | 0.87 | PTGS2 (0.57) | PTGS2SIRT1KMT2AMAPTLMNA | |
| Iodide SCHEMBL8515613 | 0.85 | PTGS2 (0.56) | PTGS2SIRT1KMT2AMAPTLMNA | |
| SCHEMBL3356549 | 0.85 | SIRT1 (0.55) | SIRT1KMT2AMAPTLMNACYP1A2 | |
| SCHEMBL6779779 | 0.84 | CYP1A2 (0.62) | PTGS2KMT2AMAPTLMNACYP3A4 | |
| SCHEMBL26942233 | 0.84 | PTGS2 (0.58) | PTGS2KMT2AMAPTCYP1A2HSD17B10 | |
| SCHEMBL6939482 | 0.83 | KMT2A (0.50) | PTGS2KMT2ALMNAHSD17B10ALDH1A1 | |
| SCHEMBL1013654 | 0.81 | HSD17B10 (0.62) | KMT2ALMNAHSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780883-B2 | ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS; ANTILIPEMIC AGENTS; RESTENOSIS; DIETETICS | WARNER-LAMBERT COMPANY | 2004-08-24 | — | — | US | disclosed |