Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 15/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645365 | 0.85 | ALOX5 (0.74) | ALOX5ALDH1A1 | |
| SCHEMBL9645694 | 0.78 | ALOX5 (1.00) | ALOX5 | |
| SCHEMBL9454642 | 0.76 | ATM (0.64) | ALOX5ATMSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10144997 | 0.76 | ALOX5 (0.60) | ALOX5ATMSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL3097713 | 0.76 | ALOX5 (0.60) | ALOX5ATMSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9647020 | 0.74 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL2306348 | 0.74 | ALOX5 (0.58) | ALOX5ATMSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10817926 | 0.73 | ALOX5 (0.57) | ALOX5ATMSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14881542 | 0.72 | ALOX5 (0.56) | ALOX5ATMSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9644532 | 0.72 | ALOX5 (1.00) | ALOX5ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |