Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699634 | 0.89 | LMNA (0.54) | LMNACTDSP1CA2NR1H2HSP90AA1 | |
| SCHEMBL10698165 | 0.89 | LMNA (0.54) | LMNACTDSP1CA2NR1H2HSP90AA1 | |
| SCHEMBL5974403 | 0.86 | NR1H2 (0.46) | LMNACTDSP1CA2NR1H2HSP90AA1 | |
| SCHEMBL537146 | 0.86 | LMNA (0.56) | LMNACTDSP1CA2NR1H2HSP90AA1 | |
| SCHEMBL536376 | 0.86 | LMNA (0.51) | LMNACTDSP1CA2NR1H2HSP90AA1 | |
| SCHEMBL10407904 | 0.81 | NR1H2 (0.55) | LMNACTDSP1CA2NR1H2HSP90AA1 | |
| SCHEMBL10719354 | 0.81 | HDAC3 (0.51) | LMNACTDSP1HDAC3HDAC4HDAC1 | |
| SCHEMBL8364788 | 0.81 | CA2 (0.59) | LMNACTDSP1CA2NR1H2HSP90AA1 | |
| SCHEMBL3235087 | 0.80 | CA2 (0.56) | LMNACTDSP1CA2NR1H2HSP90AA1 | |
| SCHEMBL26192698 | 0.80 | LMNA (0.47) | LMNACTDSP1CA2NR1H2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322389-B1 | NOVEL ANTIARRHYTHMIC AGENTS II | Aktiebolaget Hässle (SE) | 1992-10-28 | — | — | EP | disclosed |
| US-5034411-A | Cardiovascular disorders or antiarrhythmia agents | AKTIEBOLAGET HASSLE (SE) | 1991-07-23 | — | — | US | disclosed |
| WO-1989005795-A1 | NOVEL ANTIARRHYTHMIC AGENTS II | Aktiebolaget Hässle (SE) | 1989-06-29 | — | — | WO | disclosed |
| EP-0322389-A2 | Novel antiarrhythmic agents II | Aktiebolaget Hässle (SE) | 1989-06-28 | — | — | EP | disclosed |