Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20225965 | 0.89 | ALDH1A1 (0.48) | ALDH1A1TRPA1TSHRCYP3A4TDP1 | |
| SCHEMBL21881999 | 0.89 | ALDH1A1 (0.48) | ALDH1A1TRPA1TSHRCYP3A4TDP1 | |
| SCHEMBL21694553 | 0.89 | CYP3A4 (0.50) | ALDH1A1TRPA1TSHRCYP3A4TDP1 | |
| SCHEMBL8334750 | 0.85 | CYP3A4 (0.56) | ALDH1A1TSHRCYP3A4TDP1ATM | |
| SCHEMBL15424091 | 0.85 | CYP3A4 (0.47) | ALDH1A1TRPA1TSHRCYP3A4TDP1 | |
| SCHEMBL15187368 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TRPA1TSHRCYP3A4TDP1 | |
| SCHEMBL21826261 | 0.83 | TLR4 (0.50) | ALDH1A1TRPA1TSHRCYP3A4TDP1 | |
| SCHEMBL21207416 | 0.81 | TLR4 (0.52) | ALDH1A1TRPA1TSHRCYP3A4TDP1 | |
| SCHEMBL21207449 | 0.81 | TLR4 (0.52) | ALDH1A1TRPA1TSHRCYP3A4TDP1 | |
| SCHEMBL3476036 | 0.81 | TLR4 (0.52) | ALDH1A1TRPA1TSHRCYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |