Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11705130 | 0.81 | ALDH1A1 (0.44) | L3MBTL1ALDH1A1TP53 | |
| SCHEMBL9265689 | 0.80 | CYP1A2 (0.38) | GRM2KDM4ECYP1A2HTTPTGS1 | |
| SCHEMBL150096 | 0.79 | MAOB (0.32) | — | |
| SCHEMBL5014600 | 0.78 | PTGS2 (0.39) | PTGS1PTGS2GCGRMAPK14ALDH1A1 | |
| SCHEMBL2012242 | 0.76 | MAPK1 (0.38) | HTTPTGS1PTGS2LMNATP53 | |
| SCHEMBL6131965 | 0.76 | CYP3A4 (0.35) | KDM4ECYP1A2CYP3A4HPGDCYP2C19 | |
| SCHEMBL9321438 | 0.76 | PTGS2 (0.38) | KDM4ECYP1A2CYP3A4HPGDCYP2C19 | |
| SCHEMBL2011907 | 0.76 | KDM4E (0.38) | KDM4ENPSR1PTGS1PTGS2MAPK14 | |
| SCHEMBL9650164 | 0.76 | NPC1 (0.35) | KDM4ECYP3A4HPGDHTTNPSR1 | |
| SCHEMBL9649234 | 0.74 | ALDH1A1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120848-A | Anticholesterol and antilipemic agents; hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors | GLAXO GROUP LIMITED (GB) | 1992-06-09 | — | — | US | disclosed |
| US-5013749-A | Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | disclosed |