Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TYMP | P19971 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980538 | 0.84 | ACHE (0.36) | ACHEPTGS2MAPK14CSNK1A1CSNK1D | |
| SCHEMBL4201612 | 0.79 | MAOB (0.36) | ACHEPTGS2MAPK14MAOBPTGS1 | |
| SCHEMBL9559536 | 0.78 | MAOB (0.31) | PTGS2MAOBPTGS1NPC1RAB9A | |
| SCHEMBL17514924 | 0.76 | — | — | |
| SCHEMBL455383 | 0.73 | — | — | |
| SCHEMBL17514585 | 0.73 | CYP1A1 (0.39) | PTGS2 | |
| SCHEMBL17515021 | 0.72 | — | — | |
| SCHEMBL1981264 | 0.72 | ACHE (0.36) | ACHEPTGS2PTGS1 | |
| SCHEMBL17514502 | 0.72 | HSD11B1 (0.40) | — | |
| SCHEMBL9559560 | 0.72 | ACHE (0.36) | ACHEPTGS2MAPK14PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120848-A | Anticholesterol and antilipemic agents; hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors | GLAXO GROUP LIMITED (GB) | 1992-06-09 | — | — | US | disclosed |
| US-5013749-A | Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | disclosed |